If you have trekked before at high altitude like the Everest Base Camp trek without taking Diamox, then probably you will not need it in Kilimanjaro climb. However, not to take chances, we advise trekkers to begin taking Diamox 24 to 48 hours before starting the climb and continue taking it even during the climb and up to 48 hours after reaching the top of Mt. Kilimanjaro. Since Diamox has a different effect on every different individual, it is best taken after consulting with your doctor. The normal recommended dose is usually 125 mg twice a day. Diamox reacts best to your body when you are walking or exercising and not while you are asleep, so we recommend taking it once in the morning and once at lunch time.