Absolutely not! Annapurna Base Camp trek is extremely safe except at certain stretches of the trail during unfavorable seasons.  The steep slopes of the mountain section between Deurali and Machhapuchhre Base Camp are prone to landslides during the rainy season and avalanches during the winter. Hiking up to 4,130m (13,550 feet) to reach the base of the 10^th highest mountain in the world means that trekkers are susceptible to high-altitude sickness without enough acclimatization. However, the extent of the harshness of the sickness is comparably lower than that of Everest Base Camp trek.